Enter two or more substances to analyze interactions across 5 pharmacological layers. Free. Instant. Grounded in real pharmacology.
Use the API directly:
https://bleu-system.onrender.com/api/safety-check?substances=cbd,sertraline
Replace substance names with any combination. Separate with commas.
Does substance A inhibit the enzyme that breaks down substance B? If so, B accumulates — dangerous with narrow therapeutic index drugs.
Does substance A speed up metabolism of B? St. John's Wort can make birth control ineffective this way.
Glucuronidation pathway interactions. CBD is a potent UGT inhibitor that can affect drug clearance.
P-glycoprotein, BCRP, OCT, MATE. These cellular pumps determine how much drug actually gets absorbed.
SSRIs + tramadol + kratom + dextromethorphan — combinations that risk serotonin syndrome.
Stacking GABAergic substances — benzodiazepines, alcohol, kava, valerian — multiplies sedation risk.